Three years after Miaka and Taka's adventures ended in the Universe of the Four Gods, the book has opened again. Now married with a baby on the way, Miaka and Taka are settling into their new lives. However Mayo Sakaki, a high school student infatuated with Taka, has found the Universe of the Four Gods. After opening it, Mayo is drawn into the book to become the new Priestess of Suzaku while Miaka collapses into a coma in the real world. At the hospital, the doctors find no trace of Miaka's unborn baby, as if she was never pregnant to begin with! Taka now must return to the world of the book to save his family, and all that reside within, from an unknown menace.

Taka has left the capital of Konan to search for the other two surviving Suzaku warriors. After reuniting with Chichiri and Tasuki, Taiitsukun appears to inform the trio that the other Suzaku warriors have been reborn. Chiriko and Mitsukake are the first two located, but their sealed memories and childish behavior could ruin Taka's quest.

Taka, Tasuki and Chichiri find themselves overcome with dobut as each reborn Suzaku warrior they find lacks the memories and abilities of their previous lives. Meanwhile, from beside Miaka's hospital bed, Keisuke, Yui and Tetsuya try to coax Mayo to return to the real world.

Mayo entered the Universe of the Four Gods hoping that she could win Taka's affections. However those dreams shatter when she realizes that a fake Suzaku has been using her to gather strength. Now Taka and the other Suzaku Warriors race to save Mayo, Miaka, the baby, and Konan. To make matters worse, an unknown evil entity has declared that the Universe of the Four Gods must be destroyed and its magic consumed, sending everything in the book into the void! When all seems lost an unlikely person will save them all...