On September 29, 1982, seven Chicago-area residents were suddenly stricken with a deadly illness. At first doctors were at a loss, but they soon discovered a sinister connection: all the victims had recently taken cyanide-laced Tylenol capsules. This launched an investigation that has lasted over four decades and forever changed the way medications and other goods are packaged in stores. This episode features interviews with family members of the victims, law enforcement who were first responders on that day, medical examiners and investigators on the case.

On July 5, 1998, a wealthy widow named Irene Silverman disappeared from her New York City townhouse. While police went on a frantic search for her, they had no idea the investigation would unravel one of the most shocking series of crimes they had ever seen – a trail of violence and fraud that stretched from the Bahamas to Los Angeles perpetuated by Sante and Kenny Kimes. This episode features interviews with Sante Kimes's son Kent Walker, Sante Kimes's attorney, NYPD officers who worked the case, and a journalist taken hostage by Kenny Kimes in prison.

When Iranian students stormed the US Embassy in Tehran in November 1979, they took the Embassy staff hostage and held them for 444 days. Only a handful managed to escape, but they were trapped in Iran until the CIA came up with a daring plan to bring them home. This top-secret mission was the subject of the Academy Award-winning film Argo. In this episode, several former hostages detail their time in captivity, and three of the Tehran Six escapees tell of their daring rescue.