Mihai Toma Jones is a disgraced police cell, living inside Frank's body and trying to protect it from intruders. With the help of his new teammate, a pill recently swallowed by their host, they must fight against a very serious threat who plans to kill Frank in less than 48 hours.Contrary to my expectations, this movie isn't totally animated as the series it's based on, Frank and his miserable life being filmed in reality. It wouldn't have been such a big fuss if the actors weren't completely retarded and unpleasant, playing stupid roles in a very bad manner. Not to say that it was gross in a lot of such scenes...The story is as linear, expected and simplistic as it gets, so you'd think that it can provide something through its animated part...Well it doesn't. It's animation is O.K. but nothing more, voice acting is sometimes off while the action is boring and mostly predictable, when it's not too stupid to endure. Thankfully they thought to insert some good music throughout the picture, making the experience a bit more "enjoyable".Maybe I had high expectations from this movie as the series provided a pleasant view for me as a child, but except the two main characters, it didn't have anything for me to enjoy. Unfortunately, as a whole, it's a big letdown which I cannot recommend to anyone.

OllieSuave-007 This is a very cool live-action/animated movie starring Bill Murray as Frank Detorre, who after eating some bad food contracted a life-threatening virus. In the movie, the internal organs of Frank's body is an animated world known as the City of Frank, and is where a policeman white blood cell named Osmosis Jones (Chris Rock) and a cold pill Frank took named Drix (David Hyde Pierce) attempt to stop the virus known as Drax (Lawrence Fishburne) from claiming Frank's life.I thought this movie is very clever and imaginative, putting the human body into a whole new perspective. It makes your "insides" seem like an entire and adventurous different world, where in the film the white blood cells are law enforcement officers, lymph nodes are police stations, veins are highways, blood is water/lava, stomach is a bus station, a rowdy club is a pimple, and the germs and bacteria are the criminals.Marc Hyman wrote a fun, imaginative and adventurous script for the movie, cleverly depicting (in animation) how the human body fights infections and sickness. Brothers Bobby and Peter Farrelly did a fine job directing the film, making you suspend reality and imagining your body working like it is depicted in the film. Kudos to the team who did the animation work - bright, colorful and vibrant - nothing like some of those dull-looking and washed-out CGI animation you see nowadays. And, the live-acting and voice casting were great - realistic and believable.As this movie is raged PG, there is also quite a bit of bodily humor, puns and jokes, especially involving digestion, going to the restroom, passing gas, popping pimples from the face, food in the mouth.. (you get the drill). Therefore, you may not want to eat anything while watching this movie. But overall, it's a fun movie for both kids and adults - very entertaining! Grade B+

SnoopyStyle The Farrelly brothers are dipping into the animation pool. It's colorful and primitive animation. It's pretty good, but that's not really the problem. Surprisingly the problem is Bill Murray and live action stuff.Frank Detomello is a slob. He eats a hard boiled egg covered with a deadly germ. And we travel inside Frank to see white blood cell policeman Osmosis Jones (Chris Rock) battle evil virus Thrax (Laurence Fishburne) with the help of Drix (David Hyde Pierce).Bill Murray looks awful as he gets sicker and sicker. I have to ask if we're supposed to laugh at Bill? It's just gross. Not the gross out humor that the Farrellys are known for. It isn't funny at all.The animated sections are much better. In fact I prefer they cut out the live action stuff. Chris Rock does a good voice. He has good chemistry with David Hyde Pierce's Drix. They need a few more jokes, but I like the City of Frank.

jDriftyx82 Osmosis Jones may not be the most entertaining movie of the summer of 2001. I don't think it's the funniest (That award probably belongs to 'Jay and Silent Bob Strike Back'), but it's well written and performed, and the animation is wonderful.The film is a mixture of animated scenes and live action. The live action (directed by The Farrelly Brothers) stars Bill Murray as Frank, a disgusting, slovenly pig of a father, who'll eat anything, including soft boiled eggs! Even more gross, this particular soft boiled egg has spent some time in the paws and cage of a rather feisty monkey, and as a result a nasty virus enters Frank and begins to turn his body into mush.If you like animation, Bill Murray, are into science and bodily stuff. You should check this out. It's on YouTube. Just search Osmosis Jones Part __