In 1856, a whaler arrives in Paita, Peru; on board is Herman Melville, who is astonished to learn that Manuela Sáenz, for eight years the lover of Simón Bolívar, is still alive. He calls on her, and although she will not talk to him about her life, his visit sends her to her chest of Bolívar's letters. As she reads them, the sepia-toned present gives way to flashbacks in color: she meets 'the Liberator' in 1822, becomes his lover, and also becomes a colonel in his military movement to realize the 'Gran Colombia', one nation across South America. As plague (brought by the ship) closes in on Manuela's household, so does her tempestuous story move toward Bolívar's betrayal and death.

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