In late 19th-century England, Jonathan Joestar, the young son of a wealthy landowner, meets his new adopted brother Dio Brando, who loathes him and plans to usurp his position as heir to the Joestar family. When Dio's attempts are thwarted, he transforms himself into a vampire using an ancient Stone Mask and destroys the Joestar estate. Jonathan embarks on a journey, meets new allies, and masters the Hamon martial arts technique to stop Dio, who has made world domination his new goal.

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